Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response.

ABSTRACT:

Context

Vascular calcification is a major complication of chronic renal failure, which has been identified as an active process partly driven by osteogenic transition of vascular smooth muscle cells (VSMCs). Aspirin could prevent cardiomyocyte damage by inducing heat shock response.

Objective

This study investigates the effect of aspirin on alleviating VSMC calcification.

Materials and methods

An in vitro VSMC calcification model was established by 10-day calcification induction in osteogenic medium. VSMCs were grouped as following: control group (normal medium), calcified group (osteogenic medium) and treated group (osteogenic medium with 1 or 4 mmol/L aspirin). VSMC calcification was evaluated by calcified nodules formation, intracellular calcium concentratio

SUBMITTER: Shen Q 

PROVIDER: S-EPMC8635617 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature