Convalescence plasma treatment of COVID-19: results from a prematurely terminated randomized controlled open-label study in Southern Sweden.
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ABSTRACT: Objective
Convalescent plasma has been tried as therapy for various viral infections. Early observational studies of convalescent plasma treatment for hospitalized COVID-19 patients were promising, but randomized controlled studies were lacking at the time. The objective of this study was to investigate if convalescent plasma is beneficial to hospitalized patients with COVID-19.Results
Hospitalized patients with confirmed COVID-19 and an oxygen saturation below 94% were randomized 1:1 to receive convalescent plasma in addition to standard of care or standard of care only. The primary outcome was number of days of oxygen treatment to keep saturation above 93% within 28 days from inclusion. The study was prematurely terminated when thirty-one of 100 intended patients had been included. The median time of oxygen treatment among survivors was 11 days (IQR 6-15) for the convalescent plasma group and 7 days (IQR 5-9) for the standard of care group (p = 0.4, median difference -4). Two patients in the convalescent plasma group and three patients in the standard of care group died (p = 0.64, OR 0.49, 95% CI 0.08-2.79). Thus no significant differences were observed between the groups. Trial registration ClinicalTrials NCT04600440, retrospectively registered Oct 23, 2020.
SUBMITTER: Holm K
PROVIDER: S-EPMC8642769 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Convalescence plasma treatment of COVID-19: results from a prematurely terminated randomized controlled open-label study in Southern Sweden.
Holm Karin K Lundgren Maria N MN Kjeldsen-Kragh Jens J Ljungquist Oskar O Böttiger Blenda B Wikén Christian C Öberg Jonas J Fernström Nils N Rosendal Ebba E Överby Anna K AK Wigren Byström Julia J Forsell Mattias M Landin-Olsson Mona M Rasmussen Magnus M
BMC research notes 20211204 1
<h4>Objective</h4>Convalescent plasma has been tried as therapy for various viral infections. Early observational studies of convalescent plasma treatment for hospitalized COVID-19 patients were promising, but randomized controlled studies were lacking at the time. The objective of this study was to investigate if convalescent plasma is beneficial to hospitalized patients with COVID-19.<h4>Results</h4>Hospitalized patients with confirmed COVID-19 and an oxygen saturation below 94% were randomize ...[more]
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