Nickel-catalyzed electrochemical carboxylation of unactivated aryl and alkyl halides with CO₂.

ABSTRACT: Electrochemical catalytic reductive cross couplings are powerful and sustainable methods to construct C-C bonds by using electron as the clean reductant. However, activated substrates are used in most cases. Herein, we report a general and practical electro-reductive Ni-catalytic system, realizing the electrocatalytic carboxylation of unactivated aryl chlorides and alkyl bromides with CO₂. A variety of unactivated aryl bromides, iodides and sulfonates can also undergo such a reaction smoothly. Notably, we also realize the catalytic electrochemical carboxylation of aryl (pseudo)halides with CO₂ avoiding the use of sacrificial electrodes. Moreover, this sustainable and economic strategy with electron as the clean reductant features mild conditions, inexpensive catalyst,

SUBMITTER: Sun GQ 

PROVIDER: S-EPMC8648755 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature