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Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H₂O₂.

ABSTRACT: An environmentally benign protocol for the generation of nitrones from benzylic secondary amines via catalyst-free oxidation of secondary amines using H₂O₂ in MeOH or CH₃CN is described. This methodology provides a selective access to a variety of C-aryl nitrones in yields of 60 to 93%. Several studies have been performed to shed light on the reaction mechanism and the role of the solvent.

SUBMITTER: Granato AS

PROVIDER: S-EPMC8650016 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H2O2.

Granato Álisson Silva ÁS Amarante Giovanni Wilson GW Adrio Javier J

The Journal of organic chemistry 20210916 19

An environmentally benign protocol for the generation of nitrones from benzylic secondary amines via catalyst-free oxidation of secondary amines using H2O2 in MeOH or CH3CN is described. This methodology provides a selective access to a variety of C-aryl nitrones in yields of 60 to 93%. Several studies have been performed to shed light on the reaction mechanism and the role of the solvent. ...[more]

PMID: 34528787

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