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Activity-induced instabilities of brain organoids.

ABSTRACT: We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.

SUBMITTER: Thijssen K

PROVIDER: S-EPMC8651611 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Activity-induced instabilities of brain organoids.

Thijssen Kristian K Kusters Guido L A GLA Doostmohammadi Amin A

The European physical journal. E, Soft matter 20211207 12

We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids. ...[more]

PMID: 34874504

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