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Recovery of cardiac function following COVID-19 - ECHOVID-19: a prospective longitudinal cohort study.


ABSTRACT:

Aims

The degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.

Methods and results

A consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72-92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3-408.0) ng/L vs. 11.7 (5.7-24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.

Conclusion

Acute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.

SUBMITTER: Lassen MCH 

PROVIDER: S-EPMC8652600 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Recovery of cardiac function following COVID-19 - ECHOVID-19: a prospective longitudinal cohort study.

Lassen Mats C H MCH   Skaarup Kristoffer Grundtvig KG   Lind Jannie N JN   Alhakak Alia S AS   Sengeløv Morten M   Nielsen Anne B AB   Simonsen Jakob Ø JØ   Johansen Niklas D ND   Davidovski Filip S FS   Christensen Jacob J   Bundgaard Henning H   Hassager Christian C   Jabbari Reza R   Carlsen Jørn J   Kirk Ole O   Lindholm Matias G MG   Kristiansen Ole P OP   Nielsen Olav W OW   Ulrik Charlotte S CS   Sivapalan Pradeesh P   Gislason Gunnar G   Møgelvang Rasmus R   Jensen Gorm B GB   Schnohr Peter P   Søgaard Peter P   Solomon Scott D SD   Iversen Kasper K   Jensen Jens U S JUS   Schou Morten M   Biering-Sørensen Tor T  

European journal of heart failure 20211017 11


<h4>Aims</h4>The degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.<h4>Methods and results</h4>A consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by  ...[more]

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