Dataset Information

Recovery of cardiac function following COVID-19 - ECHOVID-19: a prospective longitudinal cohort study.

ABSTRACT:

Aims

The degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.

Methods and results

A consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72-92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3-408.0) ng/L vs. 11.7 (5.7-24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.

Conclusion

Acute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.

SUBMITTER: Lassen MCH

PROVIDER: S-EPMC8652600 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Publications

Recovery of cardiac function following COVID-19 - ECHOVID-19: a prospective longitudinal cohort study.

Lassen Mats C H MCH Skaarup Kristoffer Grundtvig KG Lind Jannie N JN Alhakak Alia S AS Sengeløv Morten M Nielsen Anne B AB Simonsen Jakob Ø JØ Johansen Niklas D ND Davidovski Filip S FS Christensen Jacob J Bundgaard Henning H Hassager Christian C Jabbari Reza R Carlsen Jørn J Kirk Ole O Lindholm Matias G MG Kristiansen Ole P OP Nielsen Olav W OW Ulrik Charlotte S CS Sivapalan Pradeesh P Gislason Gunnar G Møgelvang Rasmus R Jensen Gorm B GB Schnohr Peter P Søgaard Peter P Solomon Scott D SD Iversen Kasper K Jensen Jens U S JUS Schou Morten M Biering-Sørensen Tor T

European journal of heart failure 20211017 11

<h4>Aims</h4>The degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.<h4>Methods and results</h4>A consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by ...[more]

PMID: 34514713

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Project description:IntroductionCOVID-19 is an international public health crisis with more than 132 million infections worldwide. Beyond acute infection, emerging data indicate patients diagnosed with COVID-19 may experience persistent sequelae similar to survivors of sepsis or acute respiratory syndromes, including mobility limitations and fatigue. However, there is limited evidence on the trajectory of functional recovery in those hospitalised with COVID-19. The primary aim of the Coronavirus Registry Functional Recovery (COREG-FR) study is to understand the trajectory of functional recovery among individuals hospitalised for COVID-19 over the medium (up to 6 months) and longer term (6-12 months) that will guide clinical care and optimal management of serious COVID-19 illness and recovery.Methods and analysisCOREG-FR is a multicentre longitudinal cohort study. We will enrol a minimum of 211 adults age 18 years and older with COVID-19 from five hospitals. Participants will be followed from admission to hospital as an inpatient, to hospital discharge, and at 3-month, 6-month, 9-month and up to 12-month post-hospital discharge. We will conduct telephone interviews at ward admission and discharge, and telephone interviews plus in-person assessments of physical function and lung function at all remaining follow-ups. Our primary outcome is the Activity Measure for Post-Acute Care mobility scale measured at all time points. We will conduct linear mixed effects regression analyses to explore determinants of functional outcomes after COVID-19 illness. Subgroup analyses based on age (≤65 vs >65 years), frailty status (Clinical Frailty Scale score ≤4 vs >5) and variants of concern will be conducted.Ethics and disseminationCOREG-FR has been approved by Research Ethics Boards at participating sites. We will disseminate this work through peer-reviewed manuscripts, presentations at national and international meetings and through the established COREG website (www.coregontario.ca). COREG-FR is designed as a data platform for future studies evaluating COVID-19 recovery.Trial registration numberNCT04602260; Pre-results.

Dataset Information

Recovery of cardiac function following COVID-19 - ECHOVID-19: a prospective longitudinal cohort study.

Aims

Methods and results

Conclusion

Publications

Recovery of cardiac function following COVID-19 - ECHOVID-19: a prospective longitudinal cohort study.

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