Ontology highlight
ABSTRACT:
SUBMITTER: Chaitanya MVSK
PROVIDER: S-EPMC8653574 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Chaitanya M V S K MVSK Reddy P O Venkataramana POV Nikhil Kumar K Kumar Anil A Shah Kavita K Kumar Dalip D
Bioorganic & medicinal chemistry letters 20180726 17
A new library of thirteen indolylisoxazolines 6a-m has been synthesized by the treatment of indolylchalcones with hydroxylamine hydrochloride. Evaluation of anticancer activity of indolylisoxazolines 6a-m led to the identification of potent compounds 6c-d, 6i and 6l, with IC<sub>50</sub> ranging 2.5-5.0 µM against the tested cancer cell lines. Using a number of complementary techniques such as acridine orange/ethidium bromide staining, PARP1 cleavage and DNA strand breaks assay, we show that the ...[more]