Unlucky punches: the vulnerability-stress model for the development of impulse control disorders in Parkinson's disease.

ABSTRACT: Impulse-control disorders are commonly observed during dopamine-replacement therapy in Parkinson's disease, but the majority of patients seems "immune" to this side effect. Epidemiological evidence suggests that a major risk factor may be a specific difference in the layout of the dopaminergic-reinforcement system, of which the ventral striatum is a central player. A series of imaging studies of the dopaminergic system point toward a presynaptic reduction of dopamine-reuptake transporter density and dopamine synthesis capacity. Here, we review current evidence for a vulnerability-stress model in which a relative reduction of dopaminergic projections to the ventral striatum and concomitant sensitization of postsynaptic neurons represent a predisposing (hypodopaminergic) vulnerability. Stres

SUBMITTER: Theis H 

PROVIDER: S-EPMC8654901 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature