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Single neonatal irradiation induces long-term gene expression changes in the thyroid gland, which may be involved in the tumorigenesis.

ABSTRACT: Exposure to ionizing radiation in childhood has been recognized as a risk factor for thyroid cancer. We previously demonstrated that neonatal X-irradiation induced specific deformation of the thyroid follicles. Here, we further analyzed this model to understand the possible relationship with thyroid carcinogenesis. Wistar rats were subjected to cervical X-irradiation at different ages of 1-8 weeks old and at different doses of 1.5-12 Gy. For tumor promotion, rats were fed with an iodine-deficient diet (IDD). In cervically X-irradiated neonatal rats, the size of thyroid follicles decreased, accompanied by an increase in the number of TUNEL-positive cells. Fas and Lgals3 mRNA levels increased, while Mct8 and Lat4 expressions decreased. The co-administration of IDD induced the proliferation and the upregulation in Lgals3 expression, resulting in thyroid adenoma development at 28 weeks post-exposure. Our data demonstrated that single neonatal X-irradiation induced continuous apoptotic activity in the thyroid with the long-term alternation in Fas, Mct8, Lat4, and Lgals3 mRNA expressions. Some of these changes were similar to those induced by IDD, suggesting that neonatal X-irradiation may partially act as a thyroid tumor promoter. These radiation-induced thyroidal changes may be enhanced by the combined treatment with IDD, resulting in the early development of thyroid adenoma.

SUBMITTER: Fujimoto N

PROVIDER: S-EPMC8655036 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Single neonatal irradiation induces long-term gene expression changes in the thyroid gland, which may be involved in the tumorigenesis.

Fujimoto Nariaki N Matsuu-Matsuyama Mutsumi M Nakashima Masahiro M

Scientific reports 20211208 1

Exposure to ionizing radiation in childhood has been recognized as a risk factor for thyroid cancer. We previously demonstrated that neonatal X-irradiation induced specific deformation of the thyroid follicles. Here, we further analyzed this model to understand the possible relationship with thyroid carcinogenesis. Wistar rats were subjected to cervical X-irradiation at different ages of 1-8 weeks old and at different doses of 1.5-12 Gy. For tumor promotion, rats were fed with an iodine-deficien ...[more]

PMID: 34880333

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Single neonatal irradiation induces long-term gene expression changes in the thyroid gland, which may be involved in the tumorigenesis.

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Single neonatal irradiation induces long-term gene expression changes in the thyroid gland, which may be involved in the tumorigenesis.

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