Unknown

Dataset Information

0

Predictors of Change in Skin Intrinsic Fluorescence in Type 1 Diabetes: The Epidemiology of Diabetes Complications Study.


ABSTRACT:

Background

Skin intrinsic fluorescent (SIF) scores are indirect measures of advanced glycation end-products (AGEs). SIF scores are cross-sectionally associated with type 1 diabetes (T1D) complications such as increased albumin excretion rate (AER), coronary artery calcification (CAC) and neuropathy. We assessed predictors of SIF score change in those with T1D.

Methods

Data from the 30-year longitudinal Epidemiology of Diabetes Complications (EDC) study of childhood-onset T1D were used to assess AGEs measured with a SIF score produced by the SCOUT DS® device. SIF scores were assessed twice in 83 participants: between 2007-08 and again between 2010-14. Regression analyses were used to assess independent predictors of SIF score change.

Results

At baseline, mean age was 47.9 ± 6.9 years, diabetes duration was 36.7 ± 6.4 years, and median glycosylated hemoglobin (HbA1c) was 7.1 (interquartile range: 6.5, 8.5). During a mean follow-up of 5.2 ± 0.9 years, mean change in SIF score was 2.9 ± 2.8 arbitrary units. In multivariable linear regression models, log HbA1c (P < 0.001), log estimated glomerular filtration rate (eGFR) (P < 0.001), overt nephropathy (defined as AER ≥ 200 µg/min, P = 0.06), and multiple daily insulin shots/pump use (MDI) exposure years (P = 0.02) were independent predictors of SIF score change.

Conclusions

Increases in SIF score over 5 years were related to increased glycemic levels and decreased kidney function (eGFR). MDI and glomerular damage were related to a decreased SIF score. This is one of the first studies with repeated SIF assessments in T1D and provides unique, albeit preliminary, insight about these associations.

SUBMITTER: Tomaszewski EL 

PROVIDER: S-EPMC8655295 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Predictors of Change in Skin Intrinsic Fluorescence in Type 1 Diabetes: The Epidemiology of Diabetes Complications Study.

Tomaszewski Erin L EL   Orchard Trevor J TJ   Hawkins Marquis S MS   Conway Rebecca B N RBN   Buchanich Jeanine M JM   Maynard John J   Songer Thomas T   Costacou Tina T  

Journal of diabetes science and technology 20210515 6


<h4>Background</h4>Skin intrinsic fluorescent (SIF) scores are indirect measures of advanced glycation end-products (AGEs). SIF scores are cross-sectionally associated with type 1 diabetes (T1D) complications such as increased albumin excretion rate (AER), coronary artery calcification (CAC) and neuropathy. We assessed predictors of SIF score change in those with T1D.<h4>Methods</h4>Data from the 30-year longitudinal Epidemiology of Diabetes Complications (EDC) study of childhood-onset T1D were  ...[more]

Similar Datasets

| S-EPMC3781515 | biostudies-literature
| S-EPMC4575521 | biostudies-literature
| S-EPMC4915582 | biostudies-literature
2013-12-31 | GSE47385 | GEO
2016-05-15 | E-GEOD-76170 | biostudies-arrayexpress
2016-05-15 | GSE76170 | GEO
| S-EPMC3064012 | biostudies-literature
2016-05-15 | E-GEOD-76169 | biostudies-arrayexpress
| S-EPMC8225549 | biostudies-literature
2016-05-15 | GSE76169 | GEO