Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes.

ABSTRACT:

Background

Transdifferentiation describes transformation in vivo of specialized cells from one lineage into another. While there is extensive literature on forced induction of lineage reprogramming in vitro, endogenous mechanisms that govern transdifferentiation remain largely unknown. The observation that human microvascular pericytes transdifferentiate into neurons provided an opportunity to explore the endogenous molecular basis for lineage reprogramming.

Results

We show that abrupt destabilization of the higher-order chromatin topology that chaperones lineage memory of pericytes is driven by transient global transcriptional arrest. This leads within minutes to localized decompression of the repressed competing higher-order chromatin topology and expression of pro-neural

SUBMITTER: Rezaei-Lotfi S 

PROVIDER: S-EPMC8656028 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature