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Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes [DRIP-Seq]

ABSTRACT: Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes [DRIP-Seq]

PROVIDER: PRJNA777271 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16704739.fastq.gz	Fastqsanger.gz
	SRR16704740.fastq.gz	Fastqsanger.gz

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Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes [DRIP-Seq]

Project description:The observation that human microvascular pericytes transdifferentiate into neurons provided an opportunity to explore the endogenous molecular basis for lineage reprogramming. Here, we show that abrupt destabilization of the higher-order chromatin topology that chaperones lineage memory of pericytes is driven by transient global transcriptional arrest. This leads within minutes to localized decompression of the repressed competing higher-order chromatin topology and expression of pro-neural genes. Transition to neural lineage is completed by probabilistic induction of R-loops in key myogenic loci upon re-initiation of RNA polymerase activity, leading to depletion of the myogenic transcriptome and emergence of the neurogenic transcriptome.

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Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes.

Project description: Not available

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Project description:The objective of the present study is to investigate the effect of a stroke mimic condition on human brain pericytes. Comparative gene expression analysis was performed using cultured human brain microvascular pericytes with 1% oxygen for 24 hours or with acidic condition at pH 6.5 for 24 hours. Gene expression was analyzed using 3D-Gene® Human 25k oligonucleotide microarrays and computational gene expression analysis tools. Incubation of cells under these conditions resulted in significant changes in numerous genes related with glycolysis, immune responses, and angiogenesis.

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