Which Lynch syndrome screening programs could be implemented in the "real world"? A systematic review of economic evaluations.

ABSTRACT:

Purpose

Lynch syndrome (LS) screening can significantly reduce cancer morbidity and mortality in mutation carriers. Our aim was to identify cost-effective LS screening programs that can be implemented in the "real world."

Methods

We performed a systematic review of full economic evaluations of genetic screening for LS in different target populations; health outcomes were estimated in life-years gained or quality-adjusted life-years.

Results

Overall, 20 studies were included in the systematic review. Based on the study populations, we identified six categories of LS screening program: colorectal cancer (CRC)-based, endometrial cancer-based, general population-based, LS family registry-based, cascade testing-based, and genetics clinic-based screening programs. We perfor

SUBMITTER: Di Marco M 

PROVIDER: S-EPMC8660650 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature