Multiethnic genome-wide and HLA association study of total serum IgE level.

ABSTRACT:

Background

Total serum IgE (tIgE) is an important intermediate phenotype of allergic disease. Whole genome genetic association studies across ancestries may identify important determinants of IgE.

Objective

We aimed to increase understanding of genetic variants affecting tIgE production across the ancestry and allergic disease spectrum by leveraging data from the National Heart, Lung and Blood Institute Trans-Omics for Precision Medicine program; the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA); and the Atopic Dermatitis Research Network (N = 21,901).

Methods

We performed genome-wide association within strata of study, disease, and ancestry groups, and we combined results via a meta-regression approach that models heterogeneity attri

SUBMITTER: Daya M 

PROVIDER: S-EPMC8665111 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature