Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos.

ABSTRACT:

Background

IgE is a key mediator of allergic inflammation, and its levels are frequently increased in patients with allergic disorders.

Objective

We sought to identify genetic variants associated with IgE levels in Latinos.

Methods

We performed a genome-wide association study and admixture mapping of total IgE levels in 3334 Latinos from the Genes-environments & Admixture in Latino Americans (GALA II) study. Replication was evaluated in 454 Latinos, 1564 European Americans, and 3187 African Americans from independent studies.

Results

We confirmed associations of 6 genes identified by means of previous genome-wide association studies and identified a novel genome-wide significant association of a polymorphism in the zinc finger protein 365 gene (ZNF365) with tot

SUBMITTER: Pino-Yanes M 

PROVIDER: S-EPMC4458233 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature