An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos.

ABSTRACT:

Background

Asthma is a common but complex disease with racial/ethnic differences in prevalence, morbidity, and response to therapies.

Objective

We sought to perform an analysis of genetic ancestry to identify new loci that contribute to asthma susceptibility.

Methods

We leveraged the mixed ancestry of 3902 Latinos and performed an admixture mapping meta-analysis for asthma susceptibility. We replicated associations in an independent study of 3774 Latinos, performed targeted sequencing for fine mapping, and tested for disease correlations with gene expression in the whole blood of more than 500 subjects from 3 racial/ethnic groups.

Results

We identified a genome-wide significant admixture mapping peak at 18q21 in Latinos (P = 6.8 × 10^-6), where Native

SUBMITTER: Gignoux CR 

PROVIDER: S-EPMC6927816 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature