Liposomal honokiol inhibits glioblastoma growth through regulating macrophage polarization.

ABSTRACT:

Background

Glioblastoma is a type of aggressive brain tumor-related to infiltrating microglia/macrophages. Various studies have identified antitumor properties of a bioactive plant compound named honokiol, originating from the Magnolia species. This beneficial characteristic of honokiol has been discovered in many malignant tumors.

Methods

We investigated the molecular mechanisms behind the anti-glioma effects of liposomal honokiol (Lip-HNK) using qRT-PCR, Western blot, co-culture, and in vivo animal experiments.

Results

It was discovered that the expression of M1 markers such as CD11c, inducible nitric oxide synthase (iNOS), and major histocompatibility complex (MHC) II (IA/IE subregions) induced by lipopolysaccharide (LPS)/IFN-γ was increased by Lip-HN

SUBMITTER: Li S 

PROVIDER: S-EPMC8667111 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature