Integrated analysis of immune infiltration in esophageal carcinoma as prognostic biomarkers.

ABSTRACT:

Background

Esophageal cancer (EC) is one of the most aggressive and lethal malignancies in the world. The quantity and distribution of immune cells are very important factors in determining cancer. Tumor-infiltrating mast cells (TIM) are a class of immune cells with an important immune regulation function for tumor progression. However, tumor-infiltrating immune cells (TIICs) and their role in EC have not yet been investigated.

Methods

The RNA-seq data of an EC cohort were downloaded from The Cancer Genome Atlas (TCGA) website. In this study, we used the Cell-type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT) algorithm to compare different soakage of inflammatory cells in esophageal squamous cell carcinoma (ESCC) and normal tissue. Kaplan-Meier

SUBMITTER: Yin H 

PROVIDER: S-EPMC8667131 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature