Emerging Mechanisms of G₁/S Cell Cycle Control by Human and Mouse Cytomegaloviruses.

ABSTRACT: Cytomegaloviruses (CMVs) are among the largest pathogenic viruses in mammals. To enable replication of their long double-stranded DNA genomes, CMVs induce profound changes in cell cycle regulation. A hallmark of CMV cell cycle control is the establishment of an unusual cell cycle arrest at the G₁/S transition, which is characterized by the coexistence of cell cycle stimulatory and inhibitory activities. While CMVs interfere with cellular DNA synthesis and cell division, they activate S-phase-specific gene expression and nucleotide metabolism. This is facilitated by a set of CMV gene products that target master regulators of G₁/S progression such as cyclin E and A kinases, Rb-E2F transcription factors, p53-p21 checkpoint proteins, the APC/C ubiquitin ligase, and the nu

SUBMITTER: Bogdanow B 

PROVIDER: S-EPMC8669474 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature