Oxidative Metabolism as a Modulator of Kratom's Biological Actions.
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ABSTRACT:
SUBMITTER: Chakraborty S
PROVIDER: S-EPMC8673317 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Oxidative Metabolism as a Modulator of Kratom's Biological Actions.
Chakraborty Soumen S Uprety Rajendra R Slocum Samuel T ST Irie Takeshi T Le Rouzic Valerie V Li Xiaohai X Wilson Lisa L LL Scouller Brittany B Alder Amy F AF Kruegel Andrew C AC Ansonoff Michael M Varadi Andras A Eans Shainnel O SO Hunkele Amanda A Allaoa Abdullah A Kalra Sanjay S Xu Jin J Pan Ying Xian YX Pintar John J Kivell Bronwyn M BM Pasternak Gavril W GW Cameron Michael D MD McLaughlin Jay P JP Sames Dalibor D Majumdar Susruta S
Journal of medicinal chemistry 20211116 22
The leaves of <i>Mitragyna speciosa</i> (kratom), a plant native to Southeast Asia, are increasingly used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of natural products chemistry, chemical synthesis, and pharmacology, we provide a detailed <i>in vitro</i> and <i>in vivo</i> pharmacological characterization of the alkaloids in kratom. We report that metabolism of kratom's major alkaloid, mitragynine, in mice leads to formation of (a) a potent mu opioid r ...[more]
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