Combining selective serotonin reuptake inhibitors and cognitive behavioral therapy in youth with depression and anxiety.

ABSTRACT:

Background

Treatment studies of children and adolescents with internalizing disorders suggest that the combination of a selective serotonin reuptake inhibitor (SSRI) and cognitive behavioral therapy (CBT) consistently produces greater improvement than either treatment alone. We sought to determine how response to combined treatment varies across disorders (anxiety versus depression), and by specific patient characteristics.

Methods

Three large National Institutes of Health-funded trials of children and adolescents with major depression (n = 2) and anxiety disorders (n = 1) were evaluated, each comparing CBT + SSRI to SSRI only, Bayesian Hierarchical Models (BHMs) were used, for endpoint response, time course of response and predictors of response in participants who received

SUBMITTER: Strawn JR 

PROVIDER: S-EPMC8674898 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature