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Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy.

ABSTRACT: Bi-based nanomaterials, such as Bi2Se3, play an important part in biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. Polyethylenimine (PEI)-modified ultrasmall Bi2Se3 nanodots were prepared using an ultrafast synthetic method at room temperature (25°C). Bi2Se3 nanodots exhibited superior CT imaging performance, and could be used as effective photothermal reagents owing to their broad absorption in the ultraviolet-visible-near infrared region. Under irradiation at 808 nm, PEI-Bi2Se3 nanodots exhibited excellent photothermal-conversion efficiency of up to 41.3%. Good biocompatibility and significant tumor-ablation capabilities were demonstrated in vitro and in vivo. These results revealed that PEI-Bi2Se3 nanodots are safe and a good nanotheranostic platform for CT imaging-guided PTT of cancer.

SUBMITTER: Zhang P 

PROVIDER: S-EPMC8675356 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Ultrasmall PEI-Decorated Bi<sub>2</sub>Se<sub>3</sub> Nanodots as a Multifunctional Theranostic Nanoplatform for <i>in vivo</i> CT Imaging-Guided Cancer Photothermal Therapy.

Zhang Peng P   Wang Lei L   Chen Xiuying X   Li Xiang X   Yuan Qinghai Q  

Frontiers in pharmacology 20211202

Bi-based nanomaterials, such as Bi<sub>2</sub>Se<sub>3</sub>, play an important part in biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. Polyethylenimine (PEI)-modified ultrasmall Bi<sub>2</sub>Se<sub>3</sub> nanodots were prepared using an ultrafast synthetic method at room temperature (25°C). Bi<sub>2</sub>Se<sub>3</sub> nanodots exhibited superior CT imaging performance, and could be used as effective photothermal reagents owing to their broad absorption i  ...[more]

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