Transforming Growth Factor Beta Receptor 3 (TGFBR3)-Associated Membranous Nephropathy.

ABSTRACT:

Background

Membranous lupus nephritis (MLN) comprises 10%-15% of lupus nephritis and increases morbidity and mortality of patients with SLE through complications of nephrotic syndrome and chronic kidney failure. Identification of the target antigens in MLN may enable noninvasive monitoring of disease activity, inform treatment decisions, and aid in prognostication, as is now possible for idiopathic MN caused by antibodies against the phospholipase A2 receptor. Here, we show evidence for type III TGF-β receptor (TGFBR3) as a novel biomarker expressed in a subset of patients with MLN.

Methods

Mass spectrometry was used for protein discovery through enrichment of glomerular proteins by laser capture microdissection and through elution of immune complexes within MLN biops

SUBMITTER: Caza TN 

PROVIDER: S-EPMC8676385 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature