Colorectal cancer in adolescents and young adults with Lynch syndrome: a Danish register-based study.

ABSTRACT:

Objective

To assess clinicopathological predictors and prognosis in early-onset colorectal cancer (CRC) in Lynch syndrome with comparison to patients diagnosed from age 40 and up.

Design

National, retrospective register-based case-control study.

Setting

Danish national hereditary CRC register.

Participants

Individuals with Lynch syndrome diagnosed with CRC from January 1950 to June 2020. The analysis was based on 215 early-onset CRCs diagnosed between 15 and 39 years of age and 574 CRCs diagnosed at age 40-88 years.

Main outcome measures

Clinical and histopathological characteristics and survival. Confounding variables were analysed by Cox analysis.

Results

27.2% of the tumours in the Danish Lynch syndrome cohort were diagnosed under age 40. Disea

SUBMITTER: Durhuus JA 

PROVIDER: S-EPMC8679060 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature