Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders.

ABSTRACT: Precise and noninvasive theranostic methods to quantify and deplete focal iron are of crucial importance for iron-overload disorders. Here, we developed an indocyanine green (ICG)–based imaging platform to reveal Fe³⁺ in vitro and in vivo. The high sensitivity and specificity of ICG-Fe interaction facilitated MR images with a marked correlation between T₁ signal intensity ratio (T₁SIR) changes and Fe³⁺ concentration in rodent models and humans. On the basis of these findings, a rational design for coordination-driven self-assembly ICG-Lecithin (ICG/Leci) was proposed to determine Fe³⁺. The enhancement of photoacoustic signal at 890 nm with increasing Fe³⁺ concentration showed an over 600% higher linear slope th

SUBMITTER: Lin H 

PROVIDER: S-EPMC8682994 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature