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Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders.


ABSTRACT: Precise and noninvasive theranostic methods to quantify and deplete focal iron are of crucial importance for iron-overload disorders. Here, we developed an indocyanine green (ICG)–based imaging platform to reveal Fe3+ in vitro and in vivo. The high sensitivity and specificity of ICG-Fe interaction facilitated MR images with a marked correlation between T1 signal intensity ratio (T1SIR) changes and Fe3+ concentration in rodent models and humans. On the basis of these findings, a rational design for coordination-driven self-assembly ICG-Lecithin (ICG/Leci) was proposed to determine Fe3+. The enhancement of photoacoustic signal at 890 nm with increasing Fe3+ concentration showed an over 600% higher linear slope than that of T1SIR changes in animal models. ICG/Leci also promoted a 100% increase in iron depletion in the liver compared with deferoxamine. The high MR sensitivity and superior photoacoustic contrast, combined with enhanced iron depletion, demonstrate that ICG/Leci is a promising theranostic agent for simultaneous detection and treatment of iron-overload disorders.

SUBMITTER: Lin H 

PROVIDER: S-EPMC8682994 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders.

Lin Huirong H   Zhou Yu Y   Wang Jiaming J   Wang Huimeng H   Yao Tianhong T   Chen Hu H   Zheng Huili H   Zhang Yang Y   Ren En E   Jiang Lai L   Chu Chengchao C   Chen Xiaoyuan X   Mao Jingsong J   Wang Fudi F   Liu Gang G  

Science advances 20211217 51


Precise and noninvasive theranostic methods to quantify and deplete focal iron are of crucial importance for iron-overload disorders. Here, we developed an indocyanine green (ICG)–based imaging platform to reveal Fe<sup>3+</sup> in vitro and in vivo. The high sensitivity and specificity of ICG-Fe interaction facilitated MR images with a marked correlation between <i>T</i><sub>1</sub> signal intensity ratio (<i>T</i><sub>1</sub>SIR) changes and Fe<sup>3+</sup> concentration in rodent models and h  ...[more]

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