Ontology highlight
ABSTRACT:
SUBMITTER: Lin H
PROVIDER: S-EPMC8682994 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Lin Huirong H Zhou Yu Y Wang Jiaming J Wang Huimeng H Yao Tianhong T Chen Hu H Zheng Huili H Zhang Yang Y Ren En E Jiang Lai L Chu Chengchao C Chen Xiaoyuan X Mao Jingsong J Wang Fudi F Liu Gang G
Science advances 20211217 51
Precise and noninvasive theranostic methods to quantify and deplete focal iron are of crucial importance for iron-overload disorders. Here, we developed an indocyanine green (ICG)–based imaging platform to reveal Fe<sup>3+</sup> in vitro and in vivo. The high sensitivity and specificity of ICG-Fe interaction facilitated MR images with a marked correlation between <i>T</i><sub>1</sub> signal intensity ratio (<i>T</i><sub>1</sub>SIR) changes and Fe<sup>3+</sup> concentration in rodent models and h ...[more]