Polymorphism rs10105606 of LPL as a Novel Risk Factor for Microalbuminuria.

ABSTRACT:

Introduction

An important clinical feature of metabolic syndrome is abdominal obesity. Microalbuminuria is important in predicting the risk of cardiovascular and renal complications in abdominal obesity patients. However, the association between microalbuminuria polymorphism and abdominal obesity has not been conducted. The objective of this study is to analyze the genetic polymorphism of microalbuminuria in participants with metabolically unhealthy obesity (MUO).

Methods

Among 1325 MUO participants, we identified genomic loci underlying those with microalbuminuria, compared to those without microalbuminuria. Single nucleotide polymorphisms (SNPs) were selected with P < 1 × 10^-5 from the Manhattan plot. Multivariable linear regression and analysis of variance were

SUBMITTER: Lim ZW 

PROVIDER: S-EPMC8684407 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature