Dataset Information

Hepatitis E in Bangladesh: Insights From a National Serosurvey.

ABSTRACT:

Background

Hepatitis E virus (HEV) genotypes 1 and 2 are a major cause of avoidable morbidity and mortality in South Asia. Despite the high risk of death among infected pregnant women, scarce incidence data has been a contributing factor to global policy recommendations against the introduction of licensed hepatitis E vaccines, one of the only effective prevention tools.

Methods

We tested serum from a nationally representative serosurvey in Bangladesh for anti-HEV immunoglobulin G and estimated seroprevalence. We used Bayesian geostatistical models to generate high-resolution maps of seropositivity and examined variability in seropositivity by individual-level, household-level, and community-level risk factors using spatial logistic regression.

Results

We tested serum samples from 2924 individuals from 70 communities representing all divisions of Bangladesh and estimated a national seroprevalence of 20% (95% confidence interval [CI], 17%-24%). Seropositivity increased with age and male sex (odds ratio, 2.2 male vs female; 95% CI, 1.8-2.8). Community-level seroprevalence ranged widely (0-78%) with higher seroprevalence in urban areas, including Dhaka, with a 3.0-fold (95% credible interval, 2.3-3.7) higher seroprevalence than the rest of the country.

Conclusions

Hepatitis E infections are common throughout Bangladesh. Strengthening surveillance for hepatitis E, especially in urban areas, can provide additional evidence to appropriately target interventions.

SUBMITTER: Azman AS

PROVIDER: S-EPMC8687073 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Publications

Hepatitis E in Bangladesh: Insights From a National Serosurvey.

Azman Andrew S AS Paul Kishor Kumar KK Bhuiyan Taufiqur Rahman TR Koyuncu Aybüke A Salje Henrik H Qadri Firdausi F Gurley Emily S ES

The Journal of infectious diseases 20211201 12 Suppl 2

<h4>Background</h4>Hepatitis E virus (HEV) genotypes 1 and 2 are a major cause of avoidable morbidity and mortality in South Asia. Despite the high risk of death among infected pregnant women, scarce incidence data has been a contributing factor to global policy recommendations against the introduction of licensed hepatitis E vaccines, one of the only effective prevention tools.<h4>Methods</h4>We tested serum from a nationally representative serosurvey in Bangladesh for anti-HEV immunoglobulin G ...[more]

PMID: 34549775

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Dataset Information

Hepatitis E in Bangladesh: Insights From a National Serosurvey.

Background

Methods

Results

Conclusions

Publications

Hepatitis E in Bangladesh: Insights From a National Serosurvey.

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