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Ant colony optimisation of decision tree and contingency table models for the discovery of gene-gene interactions.


ABSTRACT: In this study, ant colony optimisation (ACO) algorithm is used to derive near-optimal interactions between a number of single nucleotide polymorphisms (SNPs). This approach is used to discover small numbers of SNPs that are combined into a decision tree or contingency table model. The ACO algorithm is shown to be very robust as it is proven to be able to find results that are discriminatory from a statistical perspective with logical interactions, decision tree and contingency table models for various numbers of SNPs considered in the interaction. A large number of the SNPs discovered here have been already identified in large genome-wide association studies to be related to type II diabetes in the literature, lending additional confidence to the results.

SUBMITTER: Sapin E 

PROVIDER: S-EPMC8687348 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Ant colony optimisation of decision tree and contingency table models for the discovery of gene-gene interactions.

Sapin Emmanuel E   Keedwell Ed E   Frayling Tim T  

IET systems biology 20151201 6


In this study, ant colony optimisation (ACO) algorithm is used to derive near-optimal interactions between a number of single nucleotide polymorphisms (SNPs). This approach is used to discover small numbers of SNPs that are combined into a decision tree or contingency table model. The ACO algorithm is shown to be very robust as it is proven to be able to find results that are discriminatory from a statistical perspective with logical interactions, decision tree and contingency table models for v  ...[more]

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