Effects of aging on clinical outcomes in patients receiving genotype-guided P2Y12 inhibitor selection after percutaneous coronary intervention.

ABSTRACT:

Study objective

To compare the clinical effectiveness of genotype-guided P2Y12 inhibitor selection following PCI in older patients (≥70 years) and younger patients (<70 years).

Design and setting

Single-center, retrospective, cohort study. Risk of major adverse cardiovascular or cerebrovascular events (MACCE), defined as stent thrombosis, ischemic stroke, transient ischemic attack, non-fatal acute coronary syndrome, or cardiovascular death during 12 months after PCI, was compared across genotype and antiplatelet therapy groups by proportional hazards regression in patients ≥70 years and <70 years.

Patients

1,469 patients who underwent PCI and had CYP2C19 genotype testing at a single academic medical center.

Measurements and main results

The study population was

SUBMITTER: Wood B 

PROVIDER: S-EPMC8688255 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature