Genotype-Guided P2Y₁₂ Inhibitor Therapy After Percutaneous Coronary Intervention: A Bayesian Analysis.

ABSTRACT:

Background

Among patients receiving percutaneous coronary intervention (PCI), the role of a genotype-guided approach for antiplatelet therapy compared with usual care is unclear. We conducted a Bayesian analysis of the entire TAILOR-PCI (Tailored Antiplatelet Initiation to Lessen Outcomes Due to Decreased Clopidogrel Response After Percutaneous Coronary Intervention) randomized clinical trial population to evaluate the effect of the genotype-guided antiplatelet therapy post-PCI compared with the usual care on the risk of major adverse cardiovascular events (MACE).

Methods

The primary outcome for our study was the composite of MACE (myocardial infarction, stroke, and cardiovascular death). Secondary outcomes included cardiovascular death, stroke, myocardial infarction, stent

SUBMITTER: Parcha V 

PROVIDER: S-EPMC8692353 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature