Adiposity, related biomarkers, and type 2 diabetes after gestational diabetes: The Diabetes Prevention Program.

ABSTRACT:

Objective

This study investigated associations of adiposity and adiposity-related biomarkers with incident type 2 diabetes (T2D) among parous women.

Methods

Among women in the Diabetes Prevention Program (DPP) who reported a previous live birth, circulating biomarkers (leptin, adiponectin, sex hormone-binding globulin, and alanine aminotransferase; n = 1,711) were measured at enrollment (average: 12 years post partum). Visceral (VAT) and subcutaneous adipose tissue areas at the L2-L3 region and the L3-L4 region were quantified by computed tomography (n = 477). Overall and stratified (by history of gestational diabetes mellitus [GDM]) adjusted Cox proportional hazards models were fit.

Results

Alanine aminotransferase, L2-L3 VAT, and L3-L4 VAT were positively associated

SUBMITTER: Wander PL 

PROVIDER: S-EPMC8692336 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature