Cobalt-catalyzed annulation of styrenes with α-bromoacetic acids.

ABSTRACT: We report a method for addition of α-bromophenylacetic acids to vinyl C[double bond, length as m-dash]C bonds in styrenes to afford γ-lactones. Reactions employed a simple cobalt catalyst Co(NO₃)₂·6H₂O in the presence of dipivaloylmethane (dpm) ligand. Many functionalities including halogen, ester, and nitro groups were compatible with reaction conditions. If α-bromoesters were used, vinylacetates were the major products.

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC8694682 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature