Biophysical characterization of the homodimers of HomA and HomB, outer membrane proteins of Helicobacter pylori.

ABSTRACT: Helicobacter pylori is a Gram-negative bacterium that causes chronic inflammations in the stomach area and is involved in ulcers, which can develop into gastric malignancies. H. pylori attaches and colonizes to the human epithelium using some of their outer membrane proteins (OMPs). HomB and HomA are the most studied OMPs from H. pylori as they play a crucial role in adherence, hyper biofilm formation, antibiotic resistance and are also associated with severe gastric malignancies. The role of HomA and HomB in pathogenesis concerning their structure and function has not been evaluated yet. In the present study, we explored the structural aspect of HomA and HomB proteins using various computational, biophysical and small-angle X-ray scattering (SAXS) techniques. Interestingly, the in-silico

SUBMITTER: Tamrakar A 

PROVIDER: S-EPMC8714817 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature