Rapid prototyping of cell culture microdevices using parylene-coated 3D prints.

ABSTRACT: Fabrication of microfluidic devices by photolithography generally requires specialized training and access to a cleanroom. As an alternative, 3D printing enables cost-effective fabrication of microdevices with complex features that would be suitable for many biomedical applications. However, commonly used resins are cytotoxic and unsuitable for devices involving cells. Furthermore, 3D prints are generally refractory to elastomer polymerization such that they cannot be used as master molds for fabricating devices from polymers (e.g. polydimethylsiloxane, or PDMS). Different post-print treatment strategies, such as heat curing, ultraviolet light exposure, and coating with silanes, have been explored to overcome these obstacles, but none have proven universally effective. Here, we show

SUBMITTER: O'Grady BJ 

PROVIDER: S-EPMC8717820 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature