Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage.

ABSTRACT:

Background

Frailty is a major age-associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine dinucleotide phosphate (NADPH) that is highly dependent on glucose 6-P dehydrogenase (G6PD). The G6PD-overexpressing mouse (G6PD-Tg) is protected against metabolic stresses. Our aim was to examine whether this protection delays frailty.

Methods

Old wild-type (WT) and G6PD-Tg mice were evaluated longitudinally in terms of frailty. Indirect calorimetry, transcriptomic profile, and different skeletal muscle quality markers and muscle regenerative capacity were also investigated.

Results

The percentage of frail mice was significantly lower in the G6PD-Tg th

SUBMITTER: Arc-Chagnaud C 

PROVIDER: S-EPMC8718080 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature