FosGFP expression does not capture a sensory learning-related engram in superficial layers of mouse barrel cortex.

ABSTRACT: Immediate-early gene (IEG) expression has been used to identify small neural ensembles linked to a particular experience, based on the principle that a selective subset of activated neurons will encode specific memories or behavioral responses. The majority of these studies have focused on "engrams" in higher-order brain areas where more abstract or convergent sensory information is represented, such as the hippocampus, prefrontal cortex, or amygdala. In primary sensory cortex, IEG expression can label neurons that are responsive to specific sensory stimuli, but experience-dependent shaping of neural ensembles marked by IEG expression has not been demonstrated. Here, we use a fosGFP transgenic mouse to longitudinally monitor in vivo expression of the activity-dependent gene c-fos in superf

SUBMITTER: Lee J 

PROVIDER: S-EPMC8719899 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature