Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation.

ABSTRACT: Cerium oxide nanoparticles (CeONP), having potent antioxidant properties, are highly promising nanomaterials for treatment of diseases in which oxidative stress from excessive reactive oxygen species (ROS) plays a critical role in the pathogenesis and progression. However, most previously reported CeONP formulations were not efficiently cleared from the body, precluding their clinical translation. Herein, we report ultrasmall CeONP that can mitigate activation of macrophages and subsequent acute inflammation. It is found that these CeONP can effectively scavenge reactive species, inhibit macrophage activation, and minimize their recruitment and infiltration to the inflammation site, which lead to alleviation of edema and pain hypersensitivity. Moreover, we demonstrate that CeONP can be eff

SUBMITTER: Kim J 

PROVIDER: S-EPMC8720076 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature