A new and spontaneous animal model for ankylosing spondylitis is found in cynomolgus monkeys.

ABSTRACT:

Background

Ankylosing spondylitis is a progressive, disabling joint disease that affects millions worldwide. Given its unclear etiology, studies of ankylosing spondylitis relied heavily on drug-induced or transgenic rodent models which retain only partial clinical features. There is obviously a lack of a useful disease model to conduct comprehensive mechanistic studies.

Methods

We followed a group of cynomolgus monkeys having joint lesions reported of spinal stiffness for 2 years by conducting hematological testing, radiographic examination, family aggregation analysis, pathological analysis, and genetic testing.

Results

The results confirmed that these diseased animals suffered from spontaneous ankylosing spondylitis with clinical features recapitulating human ankylo

SUBMITTER: Jia H 

PROVIDER: S-EPMC8722021 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature