Identifying Epstein-Barr virus peptide sequences associated with differential IgG antibody response.

ABSTRACT:

Background

Epstein-Barr virus (EBV) infection contributes to cancers in a fraction of seropositive individuals, but much remains to be learned about variation in EBV-directed humoral immunity in cancer-free adults.

Methods

A protein microarray was used to probe serum from 175 Taiwanese and 141 Northern European adults for immunoglobulin G (IgG) antibody responses to 115 different peptide sequences, representing protein segments or protein variants, from 45 EBV proteins. It was posited that this antibody-based approach could identify EBV peptide sequences representing immunodominant regions relevant for B-cell immunity.

Results

Analyses of 45 EBV proteins with multiple protein segments or variants printed on the array identified eight EBV peptide sequences that appear

SUBMITTER: Coghill AE 

PROVIDER: S-EPMC8724419 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature