Dataset Information

Epidemiological characterisation of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021.

ABSTRACT: By 9 December 2021, 785 SARS-CoV-2 Omicron variant cases have been identified in Denmark. Most cases were fully (76%) or booster-vaccinated (7.1%); 34 (4.3%) had a previous SARS-CoV-2 infection. The majority of cases with available information reported symptoms (509/666; 76%) and most were infected in Denmark (588/644; 91%). One in five cases cannot be linked to previous cases, indicating widespread community transmission. Nine cases have been hospitalised, one required intensive care and no deaths have been registered.

SUBMITTER: Espenhain L

PROVIDER: S-EPMC8728489 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Epidemiological characterisation of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021.

Espenhain Laura L Funk Tjede T Overvad Maria M Edslev Sofie Marie SM Fonager Jannik J Ingham Anna Cäcilia AC Rasmussen Morten M Madsen Sarah Leth SL Espersen Caroline Hjorth CH Sieber Raphael N RN Stegger Marc M Gunalan Vithiagaran V Wilkowski Bartlomiej B Larsen Nicolai Balle NB Legarth Rebecca R Cohen Arieh Sierra AS Nielsen Finn F Lam Janni Uyen Hoa JUH Lavik Kjetil Erdogan KE Karakis Marianne M Spiess Katja K Marving Ellinor E Nielsen Christian C Wiid Svarrer Christina C Bybjerg-Grauholm Jonas J Olsen Stefan Schytte SS Jensen Anders A Krause Tyra Grove TG Müller Luise L

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20211201 50

By 9 December 2021, 785 SARS-CoV-2 Omicron variant cases have been identified in Denmark. Most cases were fully (76%) or booster-vaccinated (7.1%); 34 (4.3%) had a previous SARS-CoV-2 infection. The majority of cases with available information reported symptoms (509/666; 76%) and most were infected in Denmark (588/644; 91%). One in five cases cannot be linked to previous cases, indicating widespread community transmission. Nine cases have been hospitalised, one required intensive care and no dea ...[more]

PMID: 34915977

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Project description:BackgroundIncreased immune evasion by emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and occurrence of breakthrough infections raise questions about whether coronavirus disease 2019 vaccination status affects SARS-CoV-2 viral load among those infected. This study examined the relationship between cycle threshold (Ct) value, which is inversely associated with viral load, and vaccination status at the onset of the Omicron wave onset in Ontario, Canada.MethodsUsing linked provincial databases, we compared median Ct values across vaccination status among polymerase chain reaction-confirmed Omicron variant SARS-CoV-2 cases (sublineages B.1.1.529, BA.1, and BA.1.1) between 6 and 30 December 2021. Cases were presumed to be Omicron based on S-gene target failure. We estimated the relationship between vaccination status and Ct values using multiple linear regression, adjusting for age group, sex, and symptom status.ResultsOf the 27 029 presumed Omicron cases in Ontario, the majority were in individuals who had received a complete vaccine series (87.7%), followed by unvaccinated individuals (8.1%), and those who had received a booster dose (4.2%). The median Ct value for post-booster dose individuals (18.3 [interquartile range, 15.4-22.3]) was significantly higher than that for unvaccinated (17.9 [15.2-21.6]; P = .02) and post-vaccine series individuals (17.8 [15.3-21.5]; P = .005). Post-booster dose cases remained associated with a significantly higher median Ct value than cases in unvaccinated individuals (P ≤ .001), after adjustment for covariates. Compared with values in persons aged 18-29 years, Ct values were significantly lower among most age groups >50 years.ConclusionsWhile slightly lower Ct values were observed among unvaccinated individuals infected with Omicron compared with post-booster dose cases, further research is required to determine whether a significant difference in secondary transmission exists between these groups.

Dataset Information

Epidemiological characterisation of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021.

Publications

Epidemiological characterisation of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021.

Similar Datasets

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