Dysregulation of mitochondrial and proteolysosomal genes in Parkinson's disease myeloid cells.

ABSTRACT: An increasing number of identified Parkinson's disease (PD) risk loci contain genes highly expressed in innate immune cells, yet their role in pathology is not understood. We hypothesize that PD susceptibility genes modulate disease risk by influencing gene expression within immune cells. To address this, we have generated transcriptomic profiles of monocytes from 230 individuals with sporadic PD and healthy subjects. We observed a dysregulation of mitochondrial and proteasomal pathways. We also generated transcriptomic profiles of primary microglia from brains of 55 subjects and observed discordant transcriptomic signatures of mitochondrial genes in PD monocytes and microglia. We further identified 17 PD susceptibility genes whose expression, relative to each risk allele, is altered in mo

SUBMITTER: Navarro E 

PROVIDER: S-EPMC8728893 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature