Recent Approaches to Targeting Canonical NFκB Signaling in the Early Inflammatory Response to Renal IRI.
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ABSTRACT:
SUBMITTER: Reid S
PROVIDER: S-EPMC8729839 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Recent Approaches to Targeting Canonical NF<i>κ</i>B Signaling in the Early Inflammatory Response to Renal IRI.
Reid Shelby S Scholey James W JW
Journal of the American Society of Nephrology : JASN 20210609 9
Ischemia reperfusion injury (IRI) is the most common cause of in-hospital AKI and is associated with increased morbidity and mortality. IRI is associated with an early phase of inflammation primarily regulated by the canonical NF<i>κ</i>B signaling pathway. Despite recent advances in our understanding of the pathogenesis of IRI, few therapeutic strategies have emerged. The purpose of this manuscript is to review interventions targeting NF<i>κ</i>B after IRI. ...[more]
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