Mathematical Modeling of the Gut-Bone Axis and Implications of Butyrate Treatment on Osteoimmunology.
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ABSTRACT:
SUBMITTER: Islam MA
PROVIDER: S-EPMC8730472 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
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Mathematical Modeling of the Gut-Bone Axis and Implications of Butyrate Treatment on Osteoimmunology.
Islam Mohammad Aminul MA Cook Carley V CV Smith Brenda J BJ Ford Versypt Ashlee N AN
Industrial & engineering chemistry research 20211130 49
Butyrate, a short-chain fatty acid produced by the gut microbiota, has pivotal roles in the regulation of the immune system. Recent studies have revealed that butyrate increases the differentiation of peripheral regulatory T cells in the gut-bone axis and promotes osteoblasts' bone forming activity. However, the mechanism of the therapeutic benefit of butyrate in bone remodeling remains incompletely understood. Here, we develop a multicompartment mathematical model to quantitatively predict the ...[more]
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