Fluorinated nanotubes: synthesis and self-assembly of cyclic peptide-poly(vinylidene fluoride) conjugates.

ABSTRACT: The synthesis of cyclic peptide-poly(vinylidene fluoride) (CP-PVDF) conjugates comprising (d-alt-l)-cyclopeptides as building blocks and their self-assembly into tube-like structures is described. By growing two PVDF polymeric chains from opposite sides of a preassembled cyclic-peptide macro-chain transfer agent, a PVDF-CP-PVDF conjugate was prepared. This "grafting-from" strategy, allowed the synthesis of the conjugate with high purity and using facile purification steps. The controlled self-assembly of the conjugate from DMF or DMSO solutions was carried out by addition of THF. This triggered the aggregation process that led to formation of tube-like structures. The mean length and width of the PVDF-CP-PVDF tubes were measured using atomic force microscopy (AFM) and transmission e

SUBMITTER: Folgado E 

PROVIDER: S-EPMC8734003 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature