The Prognostic Role of MYC Structural Variants Identified by NGS and FISH in Multiple Myeloma.

ABSTRACT:

Purpose

Structural variants (SV) of the MYC gene region are common in multiple myeloma and influence disease progression. However, the prognostic significance of different MYC SVs in multiple myeloma has not been clearly established.

Experimental design

We conducted a retrospective study of multiple myeloma comparing MYC SV subtypes identified by next-generation sequencing (NGS) and FISH to MYC expression and disease survival using 140 cases from Mayo Clinic and 658 cases from the MMRF CoMMpass study.

Results

MYC SVs were found in 41% of cases and were classified into nine subtypes. A correlation between the presence of a MYC SV and increased MYC expression was identified. Among the nine MYC subtypes, the non-immunoglobulin (non-Ig) insertion subtype was independently

SUBMITTER: Sharma N 

PROVIDER: S-EPMC8738776 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature