Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle.

ABSTRACT:

Aims/hypothesis

Energy-dense nutrition generally induces insulin resistance, but dietary composition may differently affect glucose metabolism. This study investigated initial effects of monounsaturated vs saturated lipid meals on basal and insulin-stimulated myocellular glucose metabolism and insulin signalling.

Methods

In a randomised crossover study, 16 lean metabolically healthy volunteers received single meals containing safflower oil (SAF), palm oil (PAL) or vehicle (VCL). Whole-body glucose metabolism was assessed from glucose disposal (R_d) before and during hyperinsulinaemic-euglycaemic clamps with D-[6,6-²H₂]glucose. In serial skeletal muscle biopsies, subcellular lipid metabolites and insulin signalling were measured before and afte

SUBMITTER: Sarabhai T 

PROVIDER: S-EPMC8741704 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature