Ontology highlight
ABSTRACT:
SUBMITTER: Ding SL
PROVIDER: S-EPMC8741925 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Experimental & molecular medicine 20211221 12
Night shift workers with disordered rhythmic mechanical loading are more prone to intervertebral disc degeneration (IDD). Our results showed that circadian rhythm (CR) was dampened in degenerated and aged NP cells. Long-term environmental CR disruption promoted IDD in rats. Excessive mechanical strain disrupted the CR and inhibited the expression of core clock proteins. The inhibitory effect of mechanical loading on the expression of extracellular matrix genes could be reversed by BMAL1 overexpr ...[more]