Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition.
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ABSTRACT:
SUBMITTER: Rimbach R
PROVIDER: S-EPMC8748652 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
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Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition.
Rimbach Rebecca R Yamada Yosuke Y Sagayama Hiroyuki H Ainslie Philip N PN Anderson Lene F LF Anderson Liam J LJ Arab Lenore L Baddou Issaad I Bedu-Addo Kweku K Blaak Ellen E EE Blanc Stephane S Bonomi Alberto G AG Bouten Carlijn V C CVC Bovet Pascal P Buchowski Maciej S MS Butte Nancy F NF Camps Stefan G J A SGJA Close Graeme L GL Cooper Jamie A JA Das Sai Krupa SK Dugas Lara R LR Ekelund Ulf U Entringer Sonja S Forrester Terrence T Fudge Barry W BW Goris Annelies H AH Gurven Michael M Hambly Catherine C El Hamdouchi Asmaa A Hoos Marije B MB Hu Sumei S Joonas Noorjehan N Joosen Annemiek M AM Katzmarzyk Peter P Kempen Kitty P KP Kimura Misaka M Kraus William E WE Kushner Robert F RF Lambert Estelle V EV Leonard William R WR Lessan Nader N Martin Corby K CK Medin Anine C AC Meijer Erwin P EP Morehen James C JC Morton James P JP Neuhouser Marian L ML Nicklas Theresa A TA Ojiambo Robert M RM Pietiläinen Kirsi H KH Pitsiladis Yannis P YP Plange-Rhule Jacob J Plasqui Guy G Prentice Ross L RL Rabinovich Roberto A RA Racette Susan B SB Raichlen David A DA Ravussin Eric E Reynolds Rebecca M RM Roberts Susan B SB Schuit Albertine J AJ Sjödin Anders M AM Stice Eric E Urlacher Samuel S SS Valenti Giulio G Van Etten Ludo M LM Van Mil Edgar A EA Wells Jonathan C K JCK Wilson George G Wood Brian M BM Yanovski Jack J Yoshida Tsukasa T Zhang Xueying X Murphy-Alford Alexia J AJ Loechl Cornelia U CU Luke Amy H AH Rood Jennifer J Schoeller Dale A DA Westerterp Klaas R KR Wong William W WW Speakman John R JR Pontzer Herman H
Nature communications 20220110 1
Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in we ...[more]
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Project description:BackgroundTotal energy expenditure (TEE) data in patients with early-stage cancer are scarce, precluding an understanding of energy requirements.ObjectiveThe objective was to cross-sectionally characterize TEE in patients with colorectal cancer (CRC) and to compare measured TEE with energy recommendations. It was hypothesized that TEE would differ according to body mass, body composition, and physical activity level (PAL) and current energy recommendations would have poor individual-level accuracy.MethodsPatients with newly diagnosed CRC had resting energy expenditure (REE) measured by indirect calorimetry and TEE by doubly labeled water. Hypermetabolism was defined as REE > 110% of that predicted from the Mifflin St.-Jeor equation. Body composition was assessed via DXA. Physical activity was determined as the ratio of TEE to REE (TEE:REE) (PAL) and residual activity energy expenditure (RAEE). TEE was compared with energy recommendations of 25-30 kcal/d and Dietary Reference Intakes (DRIs) using Bland-Altman analyses. Patients were stratified according to median BMI, PAL, and sex-specific ratio of fat mass (FM) to fat-free mass (FFM).ResultsTwenty-one patients (M:F 14:7; mean ± SD BMI: 28.3 ± 4.9 kg/m2, age: 57 ± 12 y) were included. Most (n = 20) had stage II-III disease; 1 had stage IV. Approximately half (n = 11) were hypermetabolic; TEE was not different in those with hypermetabolism and REE as a percentage of predicted was not correlated with TEE. Mean ± SD TEE was 2473 ± 499 kcal/d (range: 1562-3622 kcal/d), or 29.7 ± 6.3 kcal/kg body weight (range: 20.4-48.5 kcal/kg body weight). Mean ± SD PAL was 1.43 ± 0.27. The energy recommendation of 25 kcal/kg underestimated TEE (-12.6% ± 16.5%, P = 0.002); all energy recommendations had wide limits of agreement (the smallest was DRI with measured PAL: -21.2% to 29.3%). Patients with higher BMI and FM:FFM had higher bias using kilocalories per kilogram recommendations; bias from several recommendations was frequently lower (i.e. underestimation) in patients with higher PAL and RAEE.ConclusionsTEE variability was not reflected in energy recommendations and error was related to body weight, body composition, and physical activity. This trial was registered at clinicaltrials.gov as NCT03131921.
| S-EPMC6669058 | biostudies-literature
Project description:Endurance athletes perform periodized training in order to prepare for main competitions and maximize performance. However, the coupling between alterations of total energy expenditure (TEE), energy intake, and body composition during different seasonal training phases is unclear. So far, no systematic review has assessed fluctuations in TEE, energy intake, and/or body composition in endurance athletes across the training season. The purpose of this study was to (1) systematically analyze TEE, energy intake, and body composition in highly trained athletes of various endurance disciplines and of both sexes and (2) analyze fluctuations in these parameters across the training season.An electronic database search was conducted on the SPORTDiscus and MEDLINE (January 1990-31 January 2015) databases using a combination of relevant keywords. Two independent reviewers identified potentially relevant studies. Where a consensus was not reached, a third reviewer was consulted. Original research articles that examined TEE, energy intake, and/or body composition in 18-40-year-old endurance athletes and reported the seasonal training phases of data assessment were included in the review. Articles were excluded if body composition was assessed by skinfold measurements, TEE was assessed by questionnaires, or data could not be split between the sexes. Two reviewers assessed the quality of studies independently. Data on subject characteristics, TEE, energy intake, and/or body composition were extracted from the included studies. Subjects were categorized according to their sex and endurance discipline and each study allocated a weight within categories based on the number of subjects assessed. Extracted data were used to calculate weighted means and standard deviations for parameters of TEE, energy intake, and/or body composition.From 3589 citations, 321 articles were identified as potentially relevant, with 82 meeting all of the inclusion criteria. TEE of endurance athletes was significantly higher during the competition phase than during the preparation phase (p?<?0.001) and significantly higher than energy intake in both phases (p?<?0.001). During the competition phase, both body mass and fat-free mass were significantly higher compared to other seasonal training phases (p?<?0.05).Limitations of the present study included insufficient data being available for all seasonal training phases and thus low explanatory power of single parameters. Additionally, the classification of the different seasonal training phases has to be discussed. Male and female endurance athletes show important training seasonal fluctuations in TEE, energy intake, and body composition. Therefore, dietary intake recommendations should take into consideration other factors including the actual training load, TEE, and body composition goals of the athlete.
| S-EPMC5292109 | biostudies-literature
Project description:The aim of this study was to compare the effects of an aerobic training program with a strength training program on body composition and energy expenditure in overweight or obese (29.06?±?3.49?kg/m2) young adults (21.96?±?1.90 years). Subjects (N?=?109) were randomly assigned to one of three groups: a control group (CG), an aerobic training (AT) group and a strength training (ST) group. Training took place over twelve weeks comprising three sessions per week with each session lasting 60 to 90?minutes. Before and after the program, weight, height, body mass index, lean mass percentage and fat mass percentage were evaluated. In addition, The International Physical Activity Questionnaire-Short Form (IPAQ-SF) was used to estimate energy expenditure. The results of both aerobic training and strength training produced statistically significant improvements in weight (AT-CG?=?-2.892?kg; ST-CG?=?-2.986?kg); BMI (AT-CG?=?-1.075?kg/m2; ST-CG?=?-1.118?kg/m2); total body fat (AT-CG?=?-1529.172?g; ST-CG?=?-763.815); and total body fat percentage (AT-CG?=?-1.421%; AT-ST?=?-0.855%). These two exercise prescription models were therefore useful in reducing overweight and obesity, which could have an impact on improving the health and quality of life of individuals with these characteristics.
| S-EPMC7093463 | biostudies-literature
Project description:Body mass in humans and animals is strongly associated with the rate of heat production as defined by resting energy expenditure (REE). Beginning with the ancient Greeks up to the present time, philosophers and scientists have endeavored to understand the nature and sources of bodily heat. Today we recognize that body mass consists of organs and tissues, each of which produces a specified amount of heat at rest. An individual organ's REE can now be estimated in vivo as the product of its assumed mass-specific metabolic rate and its imaging-derived mass; whole-body REE reflects the sum of organ and tissue metabolic rates. The sizes of organs and total body mass in adults are governed by two main factors, a person's stature or height, and their level of adiposity. With greater body size, as represented by adult height independent of adiposity, organs remain stable or increase in mass according to distinct "scaling" patterns. Similarly, with greater relative adiposity organs adaptively accommodate to the increase in imposed mechanical and metabolic loading conditions. Through a detailed analysis of these stature and adiposity effects, we show how classical statistical REE prediction models can be mechanistically understood at the anatomic body composition level.
| S-EPMC6410366 | biostudies-literature
Project description:Purpose: The transition to university is often accompanied by the adoption of negative lifestyle habits, which may result in weight and fat gain. While this has been demonstrated during 1st year, little is known about subsequent years. We investigated changes in body composition, energy expenditure, and dietary/energy intake from 1st to 4th year university. Methods: Thirty-eight students (14 males, 24 females) completed a lifestyle questionnaire and had their body mass, fat mass, lean body mass (LBM), and body fat percentage (%BF) measured three times: at the beginning and end of 1st year, and end of 4th year. Results: During 1st year, body mass, fat mass, LBM, and %BF increased (+3.2 ± 3.8 kg, +2.5 ± 3.0 kg, +0.7 ± 2.1 kg, +2.3 ± 4.9%, respectively; p < 0.01), while daily energy intake and expenditure decreased (-359 ± 1019 kcal·d-1 and -434 ± 786 kcal·d-1, respectively; p < 0.01). Between the end of 1st year and end of 4th year, body mass, LBM, and energy expenditure increased (+3.2 ± 3.8 kg, +1.3 ± 2.9 kg, +209 ± 703 kcal·d-1, respectively; p ≤ 0.05), while %BF, fat mass, and energy intake did not change. Conclusions: Although %BF and fat mass remained stable from the end of 1st year to the end of 4th year in this group of university students, the positive increase in energy expenditure was not enough to reverse the weight and fat gained during 1st year.
| S-EPMC8070372 | biostudies-literature
Project description:Weight regain following intentional weight loss may negatively impact body composition, accelerating fat regain and increasing risk of physical disability. The purpose of this study was to compare long-term changes in whole body and thigh composition in obese older adults who intentionally lost and then partially regained weight to obese older adults who remained weight stable.This pilot study analyzed total body (dual-energy X-ray absorptiometry (DXA)) and thigh (computed tomography (CT)) composition data collected from 24 older (65-79 years) adults 18 months after completion of a 5-month randomized trial that compared resistance training alone (RT) with RT plus caloric restriction (RT+CR).Mean loss of body mass in the RT+CR group (n=13) was 7.1±2.4 kg during the 5-month intervention (74% fat mass; 26% lean mass; all P<0.01), whereas RT (n=11) remained weight stable (+0.3±1.8 kg; P=0.64). Differential group effects were observed for all DXA and CT body composition measures at 5 months (all P⩽0.01); however, by 23 months, group differences persisted only for total body (RT+CR: 81.6±10.0 kg vs RT: 88.5±14.9 kg; P=0.03) and lean (RT+CR: 50.8±9.3 kg vs RT: 54.4±12.0 kg; P<0.01) mass. All RT+CR participants regained weight from 5 to 23 months (mean gain=+4.8±2.6 kg; P<0.01). Total fat mass and all thigh fat volumes increased, whereas thigh muscle volume decreased, during the postintervention follow-up in RT+CR (all P⩽0.01). In the RT group, body mass did not change from 5 to 23 months (-0.2±0.9 kg; P=0.87). Decreased total thigh volume, driven by the loss of thigh muscle volume, were the only postintervention body composition changes observed in the RT group (both P<0.04).Short-term body composition benefits of an RT+CR intervention may be lost within 18 months after completion of the intervention.
| S-EPMC4855260 | biostudies-other
Project description:BackgroundThe carbohydrate-insulin model of obesity posits that habitual consumption of a high-carbohydrate diet sequesters fat within adipose tissue because of hyperinsulinemia and results in adaptive suppression of energy expenditure (EE). Therefore, isocaloric exchange of dietary carbohydrate for fat is predicted to result in increased EE, increased fat oxidation, and loss of body fat. In contrast, a more conventional view that "a calorie is a calorie" predicts that isocaloric variations in dietary carbohydrate and fat will have no physiologically important effects on EE or body fat.ObjectiveWe investigated whether an isocaloric low-carbohydrate ketogenic diet (KD) is associated with changes in EE, respiratory quotient (RQ), and body composition.DesignSeventeen overweight or obese men were admitted to metabolic wards, where they consumed a high-carbohydrate baseline diet (BD) for 4 wk followed by 4 wk of an isocaloric KD with clamped protein. Subjects spent 2 consecutive days each week residing in metabolic chambers to measure changes in EE (EEchamber), sleeping EE (SEE), and RQ. Body composition changes were measured by dual-energy X-ray absorptiometry. Average EE during the final 2 wk of the BD and KD periods was measured by doubly labeled water (EEDLW).ResultsSubjects lost weight and body fat throughout the study corresponding to an overall negative energy balance of ∼300 kcal/d. Compared with BD, the KD coincided with increased EEchamber (57 ± 13 kcal/d, P = 0.0004) and SEE (89 ± 14 kcal/d, P < 0.0001) and decreased RQ (-0.111 ± 0.003, P < 0.0001). EEDLW increased by 151 ± 63 kcal/d (P = 0.03). Body fat loss slowed during the KD and coincided with increased protein utilization and loss of fat-free mass.ConclusionThe isocaloric KD was not accompanied by increased body fat loss but was associated with relatively small increases in EE that were near the limits of detection with the use of state-of-the-art technology. This trial was registered at clinicaltrials.gov as NCT01967563.
| S-EPMC4962163 | biostudies-literature
Project description:Age-related alterations in whole body composition, particularly, reduced fat free mass (FFM) and increased fat mass (FM), lead to a progressive decline in resting energy expenditure (REE). Similarly, regional body composition and fat distribution changes with age might also contribute to an overall lower REE. This study investigated the influence of age on REE, regional body composition and fat distribution, including subcutaneous fat (SF) and visceral fat (VF), in a Chinese Han population as well as their contributions to age-related changes in REE. One hundred and two males aged 31-83 years old underwent dual-energy X-ray absorptiometry (DXA) which measured whole body and regional FM and FFM. SF and VF were measured by magnetic resonance imaging (MRI) and REE by indirect calorimetry. Age was significantly negatively correlated with REE (r = -0.37), total FFM (r = -0.25), upper limbs FFM (r = -0.32), lower limbs FFM (r = -0.34) and showed positive association with trunk FFM (β=0.926). FM, SF and VF decreased in older age groups after an initial rise up to 55-65 years. REE correlated positively to FM, FFM, SF, VF and showed significant association with age (β = -0.254) independent of age-associated changes in body composition. The regional alterations in body composition with age were explained by changes in trunk FFM (β = 0.926). Age-related decline in REE were not solely due to alterations in FM and FFM. Therefore, the changes in regional body composition, fat distribution and REE which occur during aging could be explained by disparities in race, ethnicity, diet, physical activity, and lower specific metabolic rates of FFM components.
| S-EPMC6286433 | biostudies-literature
Project description:ObjectivesAn energetically demanding environment like a wilderness expedition can lead to potent stressors on human physiology and homeostatic balance causing shifts in energy expenditure and body composition. These shifts likely have consequences on overall health and performance and may potentially differ by sex. It is therefore critical to understand the potential differential body composition and energy expenditure changes in response to a novel and challenging environment in both males and female bodies.MethodsData were collected from 75 healthy individuals (female = 41; ages 18-53) throughout a 3-month long expedition in the American Rockies. Body mass, body fat, and lean muscle mass were measured before, during, and after the course. Physical activity intensity and energy expenditure were also measured in a subset of participants using the wGT3X-BT Actigraph wrist monitor and an accompanying Bluetooth heart rate monitor.ResultsOver the 3-month period, individuals initially experienced declines in body mass, body fat percentage, and lean muscle mass. Participants partially rebounded from these deficits to maintain overall body mass with a slight recomposition of body fat and lean muscle mass. Our data also demonstrated that sex moderated total energy expenditure, where females experienced a modest decline whereas males experienced an increase in energy expenditure from the beginning to the end of the course.ConclusionsUnderstanding changes in energy storage in the body and variation in energy expenditure between sexes during a 3-month expedition has critical implications for maintaining health and performance in an energetically demanding environment where resources may be scarce.
| S-EPMC8712621 | biostudies-literature
Project description:Backgroundthe deleterious changes in body composition that occur during the year after hip fracture are associated with increased disability, recurrent fracture, and mortality. While the majority of these unfavourable changes have been shown to occur during the first 2 months after fracture, potential changes in body composition occurring earlier than 2 months post-fracture have not been studied. Accordingly, the aim of this study was to rigorously assess short-term changes in body composition after hip fracture.Methodstotal body mass, lean mass, fat mass and total hip and femoral neck bone mineral density (BMD) were assessed via dual energy X-ray absorptiometry at 3 days, 10 days and 2 months post-fracture among 155 hip fracture patients from the Baltimore Hip Studies. Longitudinal regression analysis using mixed models was conducted to model short-term changes in body composition.Resultsno significant changes in body composition were revealed from 3- to 10 days post-fracture. However, significant decreases from 10 days to 2 months post-fracture were noted in the total body mass (-1.95 kg, P < 0.001), lean mass (-1.73 kg, P < 0.001), total hip BMD (-0.00812 g/cm(2), P = 0.04) and femoral neck BMD (-0.015 g/cm(2), P = 0.03). No meaningful changes in fat mass were uncovered.Conclusionsthe adverse changes in body composition during the first 2 months after hip fracture appear to have occurred primarily between 10 days and 2 months post-fracture. More research is needed to determine how these findings might help inform the optimal timing of interventions aimed at improving body composition and related outcomes after hip fracture.
| S-EPMC3927774 | biostudies-literature