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Robust and durable serological response following pediatric SARS-CoV-2 infection.

ABSTRACT: The quality and persistence of children's humoral immune response following SARS-CoV-2 infection remains largely unknown but will be crucial to guide pediatric SARS-CoV-2 vaccination programs. Here, we examine 548 children and 717 adults within 328 households with at least one member with a previous laboratory-confirmed SARS-CoV-2 infection. We assess serological response at 3-4 months and 11-12 months after infection using a bead-based multiplex immunoassay for 23 human coronavirus antigens including SARS-CoV-2 and its Variants of Concern (VOC) and endemic human coronaviruses (HCoVs), and additionally by three commercial SARS-CoV-2 antibody assays. Neutralization against wild type SARS-CoV-2 and the Delta VOC are analysed in a pseudotyped virus assay. Children, compared to adults, are five times more likely to be asymptomatic, and have higher specific antibody levels which persist longer (96.2% versus 82.9% still seropositive 11-12 months post infection). Of note, symptomatic and asymptomatic infections induce similar humoral responses in all age groups. SARS-CoV-2 infection occurs independent of HCoV serostatus. Neutralization responses of children and adults are similar, although neutralization is reduced for both against the Delta VOC. Overall, the long-term humoral immune response to SARS-CoV-2 infection in children is of longer duration than in adults even after asymptomatic infection.

SUBMITTER: Renk H

PROVIDER: S-EPMC8748910 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Robust and durable serological response following pediatric SARS-CoV-2 infection.

Renk Hanna H Dulovic Alex A Seidel Alina A Becker Matthias M Fabricius Dorit D Zernickel Maria M Junker Daniel D Groß Rüdiger R Müller Janis J Hilger Alexander A Bode Sebastian F N SFN Fritsch Linus L Frieh Pauline P Haddad Anneke A Görne Tessa T Remppis Jonathan J Ganzemueller Tina T Dietz Andrea A Huzly Daniela D Hengel Hartmut H Kaier Klaus K Weber Susanne S Jacobsen Eva-Maria EM Kaiser Philipp D PD Traenkle Bjoern B Rothbauer Ulrich U Stich Maximilian M Tönshoff Burkhard B Hoffmann Georg F GF Müller Barbara B Ludwig Carolin C Jahrsdörfer Bernd B Schrezenmeier Hubert H Peter Andreas A Hörber Sebastian S Iftner Thomas T Münch Jan J Stamminger Thomas T Groß Hans-Jürgen HJ Wolkewitz Martin M Engel Corinna C Liu Weimin W Rizzi Marta M Hahn Beatrice H BH Henneke Philipp P Franz Axel R AR Debatin Klaus-Michael KM Schneiderhan-Marra Nicole N Janda Ales A Elling Roland R

Nature communications 20220110 1

The quality and persistence of children's humoral immune response following SARS-CoV-2 infection remains largely unknown but will be crucial to guide pediatric SARS-CoV-2 vaccination programs. Here, we examine 548 children and 717 adults within 328 households with at least one member with a previous laboratory-confirmed SARS-CoV-2 infection. We assess serological response at 3-4 months and 11-12 months after infection using a bead-based multiplex immunoassay for 23 human coronavirus antigens inc ...[more]

PMID: 35013206

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Project description:ObjectiveTo determine clinical and ethnodemographic correlates of serological responses against the SARS-CoV-2 spike glycoprotein following mild-to-moderate COVID-19.DesignA retrospective cohort study of healthcare workers who had self-isolated due to COVID-19.SettingUniversity Hospitals Birmingham NHS Foundation Trust, UK (UHBFT).Participants956 health care workers were recruited by open invitation via UHBFT trust email and social media.InterventionParticipants volunteered a venous blood sample that was tested for the presence of anti-SARS-CoV-2 spike glycoprotein antibodies. Results were interpreted in the context of the symptoms of their original illness and ethnodemographic variables.ResultsUsing an assay that simultaneously measures the combined IgG, IgA and IgM response against the spike glycoprotein (IgGAM), the overall seroprevalence within this cohort was 46.2% (n=442/956). The seroprevalence of immunoglobulin isotypes was 36.3%, 18.7% and 8.1% for IgG, IgA and IgM respectively. IgGAM identified serological responses in 40.6% (n=52/128) of symptomatic individuals who reported a negative SARS-CoV-2 PCR test. Increasing age, non-white ethnicity and obesity were independently associated with greater IgG antibody response against the spike glycoprotein. Self-reported fever and fatigue were associated with greater IgG and IgA responses against the spike glycoprotein. The combination of fever and/or cough and/or anosmia had a positive predictive value of 92.3% for seropositivity.Conclusions and relevanceAssays employing combined antibody detection demonstrate enhanced seroepidemiological sensitivity and can detect prior viral exposure even when PCR swabs have been negative. We demonstrate an association between known ethnodemographic risk factors associated with mortality from COVID-19 and the magnitude of serological responses in mild-to-moderate disease. The combination of cough, and/or fever and/or anosmia identifies the majority of individuals who should self-isolate for COVID-19.

Dataset Information

Robust and durable serological response following pediatric SARS-CoV-2 infection.

Publications

Robust and durable serological response following pediatric SARS-CoV-2 infection.

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