Identification of prognostic biomarkers in papillary renal cell carcinoma and PTTG1 may serve as a biomarker for predicting immunotherapy response.

ABSTRACT:

Objective

This study aims to identify potential prognostic and therapeutic biomarkers in papillary renal cell carcinoma (pRCC).

Methods

Two microarray datasets were downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified. The protein-protein interaction (PPI) networks and functional annotations of DEGs were established. Survival analysis was utilized to evaluate the prognostic significance of the DEGs and the association between the expression level of candidate biomarkers and various tumour-infiltrating immune cells was explored. The role of PTTG1 in tumour microenvironments (TME) was further explored using Single-cell RNA-seq and its prognostic and therapeutic significance was validated in Fudan University

SUBMITTER: Tian X 

PROVIDER: S-EPMC8765283 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature